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KMID : 0370220180620040257
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Yakhak Hoeji
2018 Volume.62 No. 4 p.257 ~ p.261
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Synthesis and Acetylcholinesterase Inhibitory Activity of Coumarin Carboxylates and Carboxamides Analogs
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Vo Duy Viet
Lee Dong-Hyun
Park Hae-Il
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Abstract
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everal coumarin-3-carboxylates and 3?carboxamides were synthesized and evaluated for their AChE inhibitory activity. The coumarin analogs were designed through a hybridization approach in which the backbone moiety of acetylcholine and the coumarin ring scaffold were connected together with an ester or amide linker. Most coumarin analogs exhibited weak to moderate AChE inhibitory activity. Among 6 tested compounds, 4f exhibited the best result (IC50= 17.32 μM).
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KEYWORD
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Alzheimer’s disease, cognition defect, acetylcholinesterase, AChE, coumarin analogs
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